Witch on DMT – For Science!

DMT is an iconic substance; one of the central ingredients of the magical potion ayahuasca, fuel for the entrancing soliloquies of Terence McKenna and the beautiful art of Pablo Amaringo. This powerful psychedelic was also the one that the fabulous Nikki Wyrd was injected with at the winter solstice last year – for science!

Nikki was a participant in an experiment conducted at Imperial College, London. In due course I’m sure she will publish exactly what happened, but she can’t share much at the moment because the experiment is ongoing (and no one wants to mess up the data). Both physiological and psychological information was collected, as subjects had the chance to take this often highly visual psychedelic in a clinical setting. The aim is to understand more about how this substance operates, its potential to help us explore how the brain (and mind) works, and the mechanisms by which it exerts its possible therapeutic effects.

brain

Actual pics of Ms Wyrd as psychonaut to follow once the research is complete!

Now anyone who has been paying attention to the fact that substances such as DMT have regularly proved (for millennia) both philosophically useful (in terms of helping people explore consciousness) and healing (in various ‘traditional’ psychedelic cultures) may wonder why we need such research? There are several answers to this, including the strategic one; that increased licensed use of psychedelics may lead to a wider social acceptance that these are valuable, rather than dangerous, substances. Another reason is that detailed scientific studies (this year will see researchers injecting people with DMT whilst inside fMRI brain scanners) can help us measure and understand exactly what happens to DMT in the body.

Science helps us to learn real data, supportable facts, which sometime challenge our assumptions. For instance; in the case of DMT it now considered something of ‘fact’ that it is produced in the pineal gland. The notion that this most visionary of chemicals is made in the third-eye chakra is a pretty cool one. This idea may have originated as a conversational suggestion from Rupert Sheldrake, and appears as a conjecture in Rick Strassman’s seminal DMT The Spirit Molecule. It’s an idea that is not without merit and it has to be said that today, 20 years after Strassman’s work, there is still research to be done on the chemistry of the pineal (at least judging by a kitchen conversation between Ben Sessa and David Luke I was party to a couple of weeks ago). However even if the pineal gland does make DMT, it appears unlikely that it could be the main source of endogenous DMT. That honour, it seems, belongs not to the ajna chakra but instead to the lungs.

A chemical cascade involving the enzyme INMT, which is always present in the lungs, could produce DMT in amounts  sufficient to create significant alterations in consciousness. The location of DMT production in the lungs also points towards an answer for why we have DMT in our bodies (and the bodies of many, many other living things) in the first place. It could be, as per the mythology, that DMT is there in order to let us crash into a universe of elves in order to impressed by their dazzling non-Euclidian architecture. It could perhaps have been encoded into us by some ancient alien race from Sirius or wherever, or sharpening Occam’s razor, or it could be something much more pragmatic and important to our biology.

What DMT is for in the body is the subject of some fascinating research by the charming Dr Ede Frecska. If you watch his video (filmed at Breaking Convention in 2015) you will get to hear what, for my money, is one of the best opening lines of any presentation on psychedelics: “I have a dream to have DMT in an ampule for IV use in every operating room, every intensive care unit, and every emergency vehicle.”

It appears that DMT acts to stop cells dying, it slows damage caused by oxidative stress and that’s why it is one of the few substances which are actively transported across the blood-brain barrier in humans (the others are glucose and vitamin C). As Ede explains in his engaging lecture there is a clear (and testable) chemical pathway, focused around the lungs, for our bodies to make DMT and for it to be rapidly absorbed by the brain for its neuroprotective benefits.

This scientific insight has lots of fascinating consequences. It means, for example, that we have a clear physiological mechanism by which the body could be flooded by psychedelic DMT at birth, perhaps at death, and when the body is under oxidative stress. Knowing this perhaps adds an additional layer to our understanding of the power of breathwork. Ritual practices such as full immersion baptism and many other body technologies for changing awareness may also make use of our endogenous DMT, encouraging the lungs to allow this psychedelic to persist in the bloodstream from where it is actively gobbled up by the brain.

I wonder whether the subjective effects of DMT echo what is going on at a cellular level? I wonder whether all those fractals, faces and, for some, the deep sense of the reality of the experience, is something that serves to stimulate us when we are in trouble? Small amounts of exogenous DMT certainly increase attentiveness, so maybe the call to ‘sit up and pay attention’ in the DMT trance is a turned up version of a biologically rooted ‘hey! Pull yourself together!’. At higher levels of endogenous DMT, the creation of an internal landscape, of the type we might encounter in the exogenous DMT trance, could be a property that serves to keep the operating system of consciousness running (i.e. awareness of an apparently objective external world) while the hardware (the brain) is under stress. Maybe DMT space is what the brain does until it can reboot, a hyperdimensional screensaver before normal consciousness comes back online? It is also interesting that current research suggests that DMT may have a directly healing effect on the brain (probably through its effect on the sigma-1 receptor).

Whether the effect of DMT on subjective experience is something that has been evolutionarily selected for, or whether it’s just one of those wacky epiphenomena (or the work of hyper-dimensional aliens…), is open to question. What is perhaps more certain, given recent research, is that those visitations by Guardian Angels, ancestors and other imaginal beings in moments of physical crisis (such as near drowning) could be visions made accessible by the production of DMT in the body. (Note, this isn’t the same as saying these things are not ‘real’ – whatever that means, see my article on the subject).

Many wonderful scientific insights into psychedelic substances will be presented later this year at the mother of all psychedelic conferences Breaking Convention. The lastest scientific investigations, funded by groups such as MAPS, The Beckley Foundation, and others, will bring cutting edge information to the conference. Add to this a goodly assortment of psychonauts, independent researchers, historians, shamans and others, and you’ve got a powerful psychedelic potion indeed! I’m pleased to know that some of the scientific data I’ll be hearing about will have been gathered with the help of practising spiritual psychonauts such as Ms Wyrd (who, probably, as a result of many years spent in meditation, was able to remain perfectly still during her DMT assay, producing electroencephalogram readings that were, according to the researchers, ‘impeccable’).

Finally, I hope and indeed pray that we can, as psychedelics ask us to do, keep our minds open as science and magic meet in our renewed quest to understand how best to use these marvelous substances.

Ahoy!

JV

STOP PRESS! More science news; a few hours before releasing this blogpost, a paper revealing the crystal structure of the human 5-HT2B receptor bound to LSD was published. Yet another speck to add to our ever-growing pile of knowledge.

 

 

Surreal Christology (part 4): The Androgyny

Part of what appeals to me about Surrealism both as an artistic school and also as a way of engaging with human experience, is the way in which it seeks to embrace experiences of fluidity and uncertainty. Surrealist art often dives deep into rich realms of the unconscious where attempts at neat categorisation quickly start coming apart at the seams. This is a twilight realm in which polarities such as animal versus human, safety versus threat and male versus female are both challenged and played with.

I have previously written about the way in which Queer theory and experience has provided for me a language for understanding the blurry liminality that I experienced in relation to my sexuality and in my spiritual explorations. Queer theory often provides an irreverent take on the complex interplay between biological sex and the way in which we perform our genders. This playfulness is as likely to be found in visual art as it is in text and for me depictions of Androgyny (both religious and secular) can help us gain insight into this strange territory.

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Frida Kahlo Self-Portrait with Cropped hair

 In the work of both Frida Kahlo and Leonora Carrington we see the way in which both of these female artists engage with depictions of the gendered body in ways which seek to disrupt many of the cultural expectations of their time. Kahlo powerfully utilised the juxtaposition of Mexican traditional dress with glorious facial hair to present a more authentic version of themselves. In both her art and life Kahlo bravely explored the fluidity of both her gender presentation and bisexuality, despite her physical disabilities and the personal turmoil she experienced. She even refused to be pigeon-holed as a Surrealist stating; “I never painted dreams. I painted my reality”. In my view artists such as Carrington and Kahlo worked with androgyny in a manner that embraced the dynamic and shifting nature of what this concept might mean. As Erin Hinz has observed in assessing themes of androgyny within Carrington’s work:

“Carrington experienced the social limits of her female body and choose to create bodies that fused these restrictive codes with animals, ancient ideologies in an alchemical way that transmuted these base constructions into precious, mystical and complex expressions of identity.”

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Self-portrait: The Inn of the Dawn Horse, 1937-38 Leonora Carrington

While the interplay of both male and female aspects of the self was lauded in the works of Jung and first wave feminists (cf. Virginia Woolf’s iconic Orlando) others have been less than keen. While the call of these early writers was taken up by later luminaries such as June Singer and Carolyn Heilbrun, some second wave Feminist theologians such as Mary Daly saw it as an escapist trap that “sucks spellbound victims into itself”. From the perspective of her radical separatism, Daly viewed it as an attack on both the essential potency of womanhood (“Why do I need to be half-male?”) and an attempt to falsely reify certain qualities of humanity as being polarised “male” or “female”. From such a perspective, the aspiration towards androgyny amounts to a form of sexual sublimation and fantasy that distances women from the visceral experience of female embodiment and passion.

While such voices need to be part of dialogue concerning androgyny, it could be argued that while they are seeking to challenge ideas of stereotyping and gendered fixity, via their biological essentialism they may be in danger of another existential cul de sac.  While concepts of androgyny may well be in danger of minimising difference and a true valuing of women’s experience, the desire for such an essential separateness also risks missing experiences of playfulness and exploration that seem vital to shared human experience.

For me the challenging deconstruction offered by third wave feminisms and Queer theory, is less about the removal of category and difference and more about a willingness to dance and blur at the edges of where we think such borders lie. There seems to be a psychological complexity to such approaches that allows for the power of dreams and the unconscious in allowing the primacy of the experimental and experiential. Perhaps we are back with the Trickster in prophetically destabilising neat categorisation and asking for the space to be uncertain and to explore.

This queered vision of androgyny provides a sigil for challenging and shifting our sense of what we think we think we know. This androgynous mystery acts a mirror via which deeper aspects of self might be gleaned. Whether when gazing at our own reflection or in viewing the other, the presence of such oscillating fluidity can provide the possibility of change, and with change, hope.

In relation to my own journey I have already sought to describe how my initial flight into Christianity was largely related to my adolescent confusion about the fluidity of my own sexuality and gender identity. Despite the damaging efforts of my self-suppression, I experienced at least a part of my liberation via my encounter with the Queer androgyny of Christ.

While owning my own needs and bias, I eventually encountered in my reading of Jesus a blurry ambiguity that that provided for me an alternative mode of being. This was the Jesus who cleared Temples and overturned tables, but also who blessed the gentle and sought out the one lost sheep. At a more cosmic level he was also the mythic Christ of the Gnostics, who as the “first Adam” existed in some spacey realm in which they at once contained many genders while being also beyond them. This metaphysical fluidity – while looking decidedly freaky to my fellow seminarians – provided me with a doorway via which I could begin a new chapter of greater self-understanding. Such explorations are definitely ongoing, and continue to this day.

SD

 

Reading List:

Ellen Goldberg: The Lord Who is Half Woman: Adhanarishvara in Indian and Feminist Perspective 2012

Carolyn Heilbrun: Towards a Recognition of Androgyny 1993

Erin Hinz: The Work of Leonora Carrington: An Alchemical Transmutation of Gender through Magic, Animals, and Narrative

http://genderstudies.nd.edu/assets/64258/e_hinz_the_work_of_leonora_carrington.pdf

June Singer: Androgyny: Toward a New Theory of Sexuality 1976